Robust Perfusion Parameter Quantification from 3D Single-Shot Multi-Delay ASL measurements

Oliver Maier, Stefan Manfred Spann, Daniela Pinter, Thomas Gattringer, Lukas Pirpamer, Christian Enzinger, Josef Pfeuffer, Rudolf Stollberger

Research output: Contribution to conferenceAbstractpeer-review


Multi-Delay single-shot ASL imaging provides accurate CBF and, in addition, ATT maps but the inherent low SNR can be challenging. State-of-the-art fitting techniques can improve the SNR in the estimated maps but typically suffer from spatial blurring. To this end, we propose a new reconstruction method with a joint TGV regularization on CBF and ATT to reconstruct sharp maps with improved noise suppression. Validation of the proposed method on a healthy subject and five stroke patients showed preservation of even small features in CBF and ATT while increasing SNR and sharpness over recent approaches.
Original languageEnglish
Publication statusPublished - 2020
Event2020 ISMRM & SMRT Virtual Conference & Exhibition: ISMRM 2020 - Virtuell, Transnationally
Duration: 8 Aug 202014 Aug 2020


Conference2020 ISMRM & SMRT Virtual Conference & Exhibition
Abbreviated titleISMRM 2020


  • BioTechMed-Graz


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