Semi-Synthetic Polysaccharide Sulfates as Anticoagulant Coatings for PET, 1 - Cellulose Sulfate

Martin Gericke; Aleš Doliška; Jan Stana; Tim Liebert; Thomas Heinze; Karin Stana-Kleinschek

doi:10.1002/mabi.201000419

Semi-Synthetic Polysaccharide Sulfates as Anticoagulant Coatings for PET, 1 - Cellulose Sulfate

Martin Gericke, Aleš Doliška, Jan Stana, Tim Liebert, Thomas Heinze^*, Karin Stana-Kleinschek

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

Abstract

In the present study, blood-compatible PET surfaces were prepared by coating with anticoagulant cellulose sulfates that were synthesized homogeneously in ionic liquids. The adsorption behavior of polysaccharides on PET films was investigated using QCM-D. It was demonstrated that pre-coating with different amino-group-containing polysaccharides improves the affinity toward cellulose sulfate. Moreover, the effect of different degrees of sulfation on the adsorption process was evaluated. Based on these results, several layer-by-layer coated PET foils were prepared that showed significantly improved blood compatibility compared to the initial untreated material. Anticoagulant cellulose sulfates, which are easily accessible by homogeneous synthesis in ionic liquids, can be used to improve the blood compatibility of PET-based materials. QCM-D studies revealed that coating with different amino-group-containing polysaccharides can improve the subsequent adsorption of an anticoagulant layer.

Original language	English
Pages (from-to)	549-556
Number of pages	8
Journal	Macromolecular Bioscience
Volume	11
Issue number	4
DOIs	https://doi.org/10.1002/mabi.201000419
Publication status	Published - 8 Apr 2011
Externally published	Yes

Keywords

Anticoagulant coatings
Blood compatibility
Cellulose sulfates
Chitosan
Layer-by-layer assemblies

ASJC Scopus subject areas

Biotechnology
Bioengineering
Biomaterials
Polymers and Plastics
Materials Chemistry

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10.1002/mabi.201000419

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title = "Semi-Synthetic Polysaccharide Sulfates as Anticoagulant Coatings for PET, 1 - Cellulose Sulfate",

abstract = "In the present study, blood-compatible PET surfaces were prepared by coating with anticoagulant cellulose sulfates that were synthesized homogeneously in ionic liquids. The adsorption behavior of polysaccharides on PET films was investigated using QCM-D. It was demonstrated that pre-coating with different amino-group-containing polysaccharides improves the affinity toward cellulose sulfate. Moreover, the effect of different degrees of sulfation on the adsorption process was evaluated. Based on these results, several layer-by-layer coated PET foils were prepared that showed significantly improved blood compatibility compared to the initial untreated material. Anticoagulant cellulose sulfates, which are easily accessible by homogeneous synthesis in ionic liquids, can be used to improve the blood compatibility of PET-based materials. QCM-D studies revealed that coating with different amino-group-containing polysaccharides can improve the subsequent adsorption of an anticoagulant layer.",

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AU - Gericke, Martin

AU - Doliška, Aleš

AU - Stana, Jan

AU - Liebert, Tim

AU - Heinze, Thomas

AU - Stana-Kleinschek, Karin

PY - 2011/4/8

Y1 - 2011/4/8

N2 - In the present study, blood-compatible PET surfaces were prepared by coating with anticoagulant cellulose sulfates that were synthesized homogeneously in ionic liquids. The adsorption behavior of polysaccharides on PET films was investigated using QCM-D. It was demonstrated that pre-coating with different amino-group-containing polysaccharides improves the affinity toward cellulose sulfate. Moreover, the effect of different degrees of sulfation on the adsorption process was evaluated. Based on these results, several layer-by-layer coated PET foils were prepared that showed significantly improved blood compatibility compared to the initial untreated material. Anticoagulant cellulose sulfates, which are easily accessible by homogeneous synthesis in ionic liquids, can be used to improve the blood compatibility of PET-based materials. QCM-D studies revealed that coating with different amino-group-containing polysaccharides can improve the subsequent adsorption of an anticoagulant layer.

AB - In the present study, blood-compatible PET surfaces were prepared by coating with anticoagulant cellulose sulfates that were synthesized homogeneously in ionic liquids. The adsorption behavior of polysaccharides on PET films was investigated using QCM-D. It was demonstrated that pre-coating with different amino-group-containing polysaccharides improves the affinity toward cellulose sulfate. Moreover, the effect of different degrees of sulfation on the adsorption process was evaluated. Based on these results, several layer-by-layer coated PET foils were prepared that showed significantly improved blood compatibility compared to the initial untreated material. Anticoagulant cellulose sulfates, which are easily accessible by homogeneous synthesis in ionic liquids, can be used to improve the blood compatibility of PET-based materials. QCM-D studies revealed that coating with different amino-group-containing polysaccharides can improve the subsequent adsorption of an anticoagulant layer.

KW - Anticoagulant coatings

KW - Blood compatibility

KW - Cellulose sulfates

KW - Chitosan

KW - Layer-by-layer assemblies

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Semi-Synthetic Polysaccharide Sulfates as Anticoagulant Coatings for PET, 1 - Cellulose Sulfate

Abstract

Keywords

ASJC Scopus subject areas

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