Steryl ester synthesis, storage and hydrolysis: A contribution to sterol homeostasis

Martina Korber; Isabella Klein; Günther Daum

doi:10.1016/j.bbalip.2017.09.002

Steryl ester synthesis, storage and hydrolysis: A contribution to sterol homeostasis

Martina Korber, Isabella Klein, Günther Daum^*

^*Corresponding author for this work

Institute of Biochemistry (6480)

Research output: Contribution to journal › Review article › peer-review

Abstract

Sterols are essential lipids of all eukaryotic cells, appearing either as free sterols or steryl esters. Besides other regulatory mechanisms, esterification of sterols and hydrolysis of steryl esters serve to buffer both an excess and a lack of free sterols. In this review, the esterification process, the storage of steryl esters and their mobilization will be described. Several model organisms are discussed but the focus was set on mammals and the yeast Saccharomyces cerevisiae. The contribution of imbalanced cholesterol homeostasis to several human diseases, namely Wolman disease, cholesteryl ester storage disease, atherosclerosis and Alzheimer's disease, Niemann-Pick type C and Tangier disease is described.

Original language	English
Pages (from-to)	1534-1545
Number of pages	12
Journal	Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids
Volume	1862
Issue number	12
DOIs	https://doi.org/10.1016/j.bbalip.2017.09.002
Publication status	Published - 1 Dec 2017

Keywords

Lipid droplet
Sterol homeostasis
Steryl ester hydrolase
Steryl ester synthase

ASJC Scopus subject areas

Molecular Biology
Cell Biology

Cooperations

NAWI Graz

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.bbalip.2017.09.002

Cite this

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title = "Steryl ester synthesis, storage and hydrolysis: A contribution to sterol homeostasis",

abstract = "Sterols are essential lipids of all eukaryotic cells, appearing either as free sterols or steryl esters. Besides other regulatory mechanisms, esterification of sterols and hydrolysis of steryl esters serve to buffer both an excess and a lack of free sterols. In this review, the esterification process, the storage of steryl esters and their mobilization will be described. Several model organisms are discussed but the focus was set on mammals and the yeast Saccharomyces cerevisiae. The contribution of imbalanced cholesterol homeostasis to several human diseases, namely Wolman disease, cholesteryl ester storage disease, atherosclerosis and Alzheimer's disease, Niemann-Pick type C and Tangier disease is described.",

keywords = "Lipid droplet, Sterol homeostasis, Steryl ester hydrolase, Steryl ester synthase",

author = "Martina Korber and Isabella Klein and G{\"u}nther Daum",

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doi = "10.1016/j.bbalip.2017.09.002",

language = "English",

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journal = "Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids",

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TY - JOUR

T1 - Steryl ester synthesis, storage and hydrolysis

T2 - A contribution to sterol homeostasis

AU - Korber, Martina

AU - Klein, Isabella

AU - Daum, Günther

PY - 2017/12/1

Y1 - 2017/12/1

N2 - Sterols are essential lipids of all eukaryotic cells, appearing either as free sterols or steryl esters. Besides other regulatory mechanisms, esterification of sterols and hydrolysis of steryl esters serve to buffer both an excess and a lack of free sterols. In this review, the esterification process, the storage of steryl esters and their mobilization will be described. Several model organisms are discussed but the focus was set on mammals and the yeast Saccharomyces cerevisiae. The contribution of imbalanced cholesterol homeostasis to several human diseases, namely Wolman disease, cholesteryl ester storage disease, atherosclerosis and Alzheimer's disease, Niemann-Pick type C and Tangier disease is described.

AB - Sterols are essential lipids of all eukaryotic cells, appearing either as free sterols or steryl esters. Besides other regulatory mechanisms, esterification of sterols and hydrolysis of steryl esters serve to buffer both an excess and a lack of free sterols. In this review, the esterification process, the storage of steryl esters and their mobilization will be described. Several model organisms are discussed but the focus was set on mammals and the yeast Saccharomyces cerevisiae. The contribution of imbalanced cholesterol homeostasis to several human diseases, namely Wolman disease, cholesteryl ester storage disease, atherosclerosis and Alzheimer's disease, Niemann-Pick type C and Tangier disease is described.

KW - Lipid droplet

KW - Sterol homeostasis

KW - Steryl ester hydrolase

KW - Steryl ester synthase

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U2 - 10.1016/j.bbalip.2017.09.002

DO - 10.1016/j.bbalip.2017.09.002

M3 - Review article

C2 - 28888831

AN - SCOPUS:85029476624

SN - 1388-1981

VL - 1862

SP - 1534

EP - 1545

JO - Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids

JF - Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids

IS - 12

ER -

Steryl ester synthesis, storage and hydrolysis: A contribution to sterol homeostasis

Abstract

Keywords

ASJC Scopus subject areas

Cooperations

UN SDGs

Access to Document

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