Synthesis and biological evaluation of novel biotin-iminoalditol conjugates

Gerit Pototschnig, Christian Morales De Csáky, Jose R Montenegro Burke, Georg Schitter, Arnold E Stütz, Chris A Tarling, Stephen G Withers, Tanja M Wrodnigg

Research output: Contribution to journalArticlepeer-review


Biotin-iminosugar conjugates of different configuration such as D-gluco, D-galacto, L-ido as well as a furanoid representative in the D-manno configuration have been synthesised and exhibit powerful inhibition of beta-glucosidase from Agrobacterium sp. with K(i) values in the range of the respective parent compounds. Such molecular probes have potential for activity-based protein profiling taking advantage of the biotin-(strept)avidin interaction.

Original languageEnglish
Pages (from-to)4077-9
Number of pages3
JournalBioorganic & Medicinal Chemistry Letters
Issue number14
Publication statusPublished - 15 Jul 2010


  • Biotin/chemical synthesis
  • Drug Evaluation, Preclinical
  • Molecular Probes
  • Sugar Alcohols/chemical synthesis


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