Non-canonical amino acids as building blocks for protein biosynthesis facilitate modifications that go far beyond classical genetic engineering. Two complementary techniques allow either site-specific or residue-specific incorporation. Accordingly, the possible modifications range from atomic changes to the alteration of the overall biophysical characteristics of a protein. In this article, we present the state of the art of this new protein engineering approach.
|Translated title of the contribution||Synthetic proteins: Protein engineering with non-canonical amino acids|
|Number of pages||4|
|Publication status||Published - 1 Feb 2012|
ASJC Scopus subject areas
- Molecular Biology