Tailor-made resealable micro(bio)reactors providing easy integration of in situ sensors

Martina Viefhues, Shiwen Sun, Donya Valikhani, Bernd Nidetzky, Elwin X. Vrouwe, Torsten Mayr, Juan M. Bolivar

Research output: Contribution to journalArticlepeer-review


Flow microreactors utilizing immobilized enzymes are of great interest in biocatalysis development. Most of the common devices are permanently closed, single-use systems, which allow limited physical and chemical surface modifications and evaluation methods. In this paper we will present resealable flowcells that overcome these limitations and moreover allow a quick and easy integration of sensor systems, because of the use of modular building blocks. The devices were utilized to study the enzyme activity of glucose oxidase immobilized on chemically modified glass surfaces under flow conditions, employing integrated optical oxygen sensors for on-line monitoring.

Original languageEnglish
Article number065012
JournalJournal of Micromechanics and Microengineering
Issue number6
Publication statusPublished - 10 May 2017


  • glucose oxidase
  • micro(bio)reactor
  • modular system
  • oxygen sensor
  • resealable flowcell

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Mechanics of Materials
  • Mechanical Engineering
  • Electrical and Electronic Engineering


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