Abstract
The characterization of the target proteins of drug molecules has become an important goal in understanding its mode of action and origin of side effects due to off-target binding. This is especially important for covalently binding drugs usually containing electrophilic moieties, which potentially can react with nucleophilic residues found in many proteins. This review gives a comprehensive overview of the use of activity-based protein profiling (ABPP) as an efficient tool for the target identification of covalently binding drugs.
Original language | English |
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Pages (from-to) | 3291-3303 |
Journal | Bioorganic & Medicinal Chemistry |
Volume | 24 |
Issue number | 1 |
DOIs | |
Publication status | Published - 2016 |
Fields of Expertise
- Human- & Biotechnology