The food processing contaminant glyoxal promotes tumour growth in the multiple intestinal neoplasia (Min) mouse model

Camilla Svendsen, Anja Hortemo Hoie, Jan Alexander, Michael Murkovic, Trine Husoy

Research output: Contribution to journalArticlepeer-review

Abstract

Glyoxal is formed endogenously and at a higher rate in the case of hyperglycemia. Glyoxal is also a food processing contaminant and has been shown to be mutagenic and genotoxic in vitro. The tumourigenic potential of glyoxal was investigated using the multiple intestinal neoplasia (Min) mouse model, which spontaneously develops intestinal tumours and is susceptible to intestinal carcinogens.C57BL/6J females were mated with Min males. Four days after mating and throughout gestation and lactation, the pregnant dams were exposed to glyoxal through drinking water (0.0125%, 0.025%, 0.05%, 0.1%) or regular tap water. Female and male offspring were housed separately from PND21 and continued with the same treatment. One group were only exposed to 0.1% glyoxal from postnatal day (PND) 21.There was no difference in the number of intestinal tumours between control and treatment groups. However, exposure to 0.1% glyoxal starting in utero and at PND21 caused a significant increase in tumour size in the small intestine for male and female mice in comparison with respective control groups. This study suggests that glyoxal has tumour growth promoting properties in the small intestine in Min mice.
Original languageEnglish
Pages (from-to)197-202
JournalFood and Chemical Toxicology
Volume94
DOIs
Publication statusPublished - 2016

Fields of Expertise

  • Human- & Biotechnology

Treatment code (Nähere Zuordnung)

  • Basic - Fundamental (Grundlagenforschung)

Fingerprint

Dive into the research topics of 'The food processing contaminant glyoxal promotes tumour growth in the multiple intestinal neoplasia (Min) mouse model'. Together they form a unique fingerprint.

Cite this