Tribo-Charging Behaviour of Inhalable Mannitol Blendswith Salbutamol Sulphate

Sarah Zellnitz, Joana Pinto, Michael Brunsteiner, Hartmuth Schröttner, Johannes Khinast, Amrit Paudel*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


The performance of carrier-based dry powder inhaler (DPI) formulations can be critically impacted by interfacial interactions driven by tribo-electrification. Therefore, the aim of the present work was to understand how distinct API particle characteristics affect the charging behaviour of blends intended for DPI delivery.
Salbutamol sulphate (SBS) particles engineered via spray-drying and jet milling were used as model APIs. D-mannitol was selected as a model carrier. The materials were characterized concerning their different particle properties and their charge was analysed alone and in blends before and after flow over a stainless-steel pipe.
The spray-dried SBS (amorphous and spherical) charged positively and to a higher extent than jet milled SBS (crystalline and acicular) that charged negatively and to a lower extent. D-mannitol charged positively and to a higher extent than the APIs. All drug-excipient blends charged negatively and differences were found between the spray-dried and jet milled SBS blends at 2% and 5% drug loads.
It was demonstrated how distinct solid-states, particle shape, size and morphology as well as different water contents of the different materials can affect tribo-charging. For their binary blends, the amount and nature of fines seem to govern inter-particle contacts critically impacting charge evolution.
Original languageEnglish
Article number80
Number of pages11
JournalPharmaceutical Research
Issue number6
Publication statusPublished - 2019


  • dry powder inhaler (DPI)
  • inhalation
  • particle/material properties
  • powder blends
  • powder processing
  • Dry Powder Inhalers
  • Excipients/chemistry
  • Humans
  • Administration, Inhalation
  • Particle Size
  • Powders/chemistry
  • Drug Carriers/chemistry
  • Surface Properties
  • Chemistry, Pharmaceutical/methods
  • Albuterol/administration & dosage
  • Mannitol/chemistry
  • dry powder inhaler(DPI)

ASJC Scopus subject areas

  • Materials Science(all)
  • Pharmacology (medical)
  • Molecular Medicine
  • Biotechnology
  • Pharmacology
  • Pharmaceutical Science
  • Organic Chemistry

Fields of Expertise

  • Advanced Materials Science


Dive into the research topics of 'Tribo-Charging Behaviour of Inhalable Mannitol Blendswith Salbutamol Sulphate'. Together they form a unique fingerprint.

Cite this