TRPC1: The housekeeper of the hippocampus

Julia Skerjanz; Lena Bauernhofer; Kerstin Lenk; Anita Emmerstorfer-Augustin; Gerd Leitinger; Florian Reichmann; Thomas Stockner; Klaus Groschner; Oleksandra Tiapko

doi:10.1016/j.ceca.2024.102933

TRPC1: The housekeeper of the hippocampus

Julia Skerjanz, Lena Bauernhofer, Kerstin Lenk, Anita Emmerstorfer-Augustin, Gerd Leitinger, Florian Reichmann, Thomas Stockner, Klaus Groschner, Oleksandra Tiapko^*

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

Abstract

The non-selective cation channel TRPC1 is highly expressed in the brain. Recent research shows that neuronal TRPC1 forms heteromeric complexes with TRPC4 and TRPC5, with a small portion existing as homotetramers, primarily in the ER. Given that most studies have focused on the role of heteromeric TRPC1/4/5 complexes, it is crucial to investigate the specific role of homomeric TRPC1 in maintaining brain homeostasis. This review highlights recent findings on TRPC1 in the brain, with a focus on the hippocampus, and compiles the latest data on modulators and their binding sites within the TRPC1/4/5 subfamily to stimulate new research on more selective TRPC1 ligands.

Original language	English
Article number	102933
Journal	Cell Calcium
Volume	123
DOIs	https://doi.org/10.1016/j.ceca.2024.102933
Publication status	Published - Nov 2024

Keywords

ER homeostasis
Hippocampus
TRPC ligands
TRPC1

ASJC Scopus subject areas

Physiology
Molecular Biology
Cell Biology

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10.1016/j.ceca.2024.102933Licence: CC BY 4.0

Cite this

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title = "TRPC1: The housekeeper of the hippocampus",

abstract = "The non-selective cation channel TRPC1 is highly expressed in the brain. Recent research shows that neuronal TRPC1 forms heteromeric complexes with TRPC4 and TRPC5, with a small portion existing as homotetramers, primarily in the ER. Given that most studies have focused on the role of heteromeric TRPC1/4/5 complexes, it is crucial to investigate the specific role of homomeric TRPC1 in maintaining brain homeostasis. This review highlights recent findings on TRPC1 in the brain, with a focus on the hippocampus, and compiles the latest data on modulators and their binding sites within the TRPC1/4/5 subfamily to stimulate new research on more selective TRPC1 ligands.",

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language = "English",

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journal = "Cell Calcium",

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T2 - The housekeeper of the hippocampus

AU - Skerjanz, Julia

AU - Bauernhofer, Lena

AU - Lenk, Kerstin

AU - Emmerstorfer-Augustin, Anita

AU - Leitinger, Gerd

AU - Reichmann, Florian

AU - Stockner, Thomas

AU - Groschner, Klaus

AU - Tiapko, Oleksandra

PY - 2024/11

Y1 - 2024/11

N2 - The non-selective cation channel TRPC1 is highly expressed in the brain. Recent research shows that neuronal TRPC1 forms heteromeric complexes with TRPC4 and TRPC5, with a small portion existing as homotetramers, primarily in the ER. Given that most studies have focused on the role of heteromeric TRPC1/4/5 complexes, it is crucial to investigate the specific role of homomeric TRPC1 in maintaining brain homeostasis. This review highlights recent findings on TRPC1 in the brain, with a focus on the hippocampus, and compiles the latest data on modulators and their binding sites within the TRPC1/4/5 subfamily to stimulate new research on more selective TRPC1 ligands.

AB - The non-selective cation channel TRPC1 is highly expressed in the brain. Recent research shows that neuronal TRPC1 forms heteromeric complexes with TRPC4 and TRPC5, with a small portion existing as homotetramers, primarily in the ER. Given that most studies have focused on the role of heteromeric TRPC1/4/5 complexes, it is crucial to investigate the specific role of homomeric TRPC1 in maintaining brain homeostasis. This review highlights recent findings on TRPC1 in the brain, with a focus on the hippocampus, and compiles the latest data on modulators and their binding sites within the TRPC1/4/5 subfamily to stimulate new research on more selective TRPC1 ligands.

KW - ER homeostasis

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KW - TRPC ligands

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DO - 10.1016/j.ceca.2024.102933

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VL - 123

JO - Cell Calcium

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TRPC1: The housekeeper of the hippocampus

Abstract

Keywords

ASJC Scopus subject areas

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