ZIF-C for targeted RNA interference and CRISPR/Cas9 based gene editing in prostate cancer

Arpita Poddar, Suneela Pyreddy, Francesco Carraro, Sudip Dhakal, Andrea Rassell, Matthew R. Field, T. Srinivasa Reddy, Paolo Falcaro, Cara M. Doherty, Ravi Shukla*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


Gene therapy is highly suited for prostate cancer (PC). Metal-organic-frameworks (MOFs) are potential gene delivery systems. Target-specific cytoplasmic and nuclear knockdown in host gene expression using ZIF-C is shown for the first time through RNAi and CRISPR/Cas9 based gene editing in PC cells. A green tea phytochemical coating enhances intracellular delivery.

Original languageEnglish
Pages (from-to)15406-15409
Number of pages4
JournalChemical Communications
Issue number98
Publication statusPublished - 21 Dec 2020

ASJC Scopus subject areas

  • Ceramics and Composites
  • Chemistry(all)
  • Materials Chemistry

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