TY - JOUR
T1 - An investigation into the relationship between Xanthan gum film coating materials and predicted oro-esophageal gliding performance for solid oral dosage forms
AU - Drumond, Nélio
AU - Stegemann, Sven
PY - 2020/12
Y1 - 2020/12
N2 - Oral drug therapy is generally provided in the form of solid oral dosage forms (SODF) that have to be swallowed and move throughout the oro-esophageal system. Previous studies have provided evidence that the oro-esophageal transit of SODF depends on their shape, size, density, and surface characteristics. To estimate the impact of SODF surface coatings during esophageal transit, an in vitro system was implemented to investigate the gliding performance across an artificial mucous layer. In this work, formulations comprised of different slippery-inducing agents combined with a common film forming agent were evaluated using the artificial mucous layer system. Xanthan gum (XG) and polyethylene glycol 1500 (PEG) were applied as film-forming agents, while carnauba wax (CW), lecithin (LE), carrageenan (CA), gellan gum (GG) and sodium alginate (SA), and their combination with sodium lauryl sulfate (SLS), were applied as slippery-inducing components. All tested formulations presented lower static friction (SF) as compared to the negative control (uncoated disc, C, F0), whereas only CW/SLS-based formulations showed similar performance to F0 regarding dynamic friction (DF). The applied multivariate analysis approach allowed a higher level of detail to the evaluation and supported a better identification of excipients and respective concentrations that are predicted to improve in vivo swallowing safety.
AB - Oral drug therapy is generally provided in the form of solid oral dosage forms (SODF) that have to be swallowed and move throughout the oro-esophageal system. Previous studies have provided evidence that the oro-esophageal transit of SODF depends on their shape, size, density, and surface characteristics. To estimate the impact of SODF surface coatings during esophageal transit, an in vitro system was implemented to investigate the gliding performance across an artificial mucous layer. In this work, formulations comprised of different slippery-inducing agents combined with a common film forming agent were evaluated using the artificial mucous layer system. Xanthan gum (XG) and polyethylene glycol 1500 (PEG) were applied as film-forming agents, while carnauba wax (CW), lecithin (LE), carrageenan (CA), gellan gum (GG) and sodium alginate (SA), and their combination with sodium lauryl sulfate (SLS), were applied as slippery-inducing components. All tested formulations presented lower static friction (SF) as compared to the negative control (uncoated disc, C, F0), whereas only CW/SLS-based formulations showed similar performance to F0 regarding dynamic friction (DF). The applied multivariate analysis approach allowed a higher level of detail to the evaluation and supported a better identification of excipients and respective concentrations that are predicted to improve in vivo swallowing safety.
KW - Artificial mucous layer system
KW - Dynamic friction
KW - Film coating materials
KW - Oro-esophageal transit
KW - Predicted gliding performance
KW - Principal component analysis
KW - Solid oral dosage forms
KW - Static friction
KW - Swallowing safety
KW - Xanthan gum
UR - http://www.scopus.com/inward/record.url?scp=85098230631&partnerID=8YFLogxK
U2 - 10.3390/pharmaceutics12121241
DO - 10.3390/pharmaceutics12121241
M3 - Article
AN - SCOPUS:85098230631
SN - 1999-4923
VL - 12
SP - 1
EP - 10
JO - Pharmaceutics
JF - Pharmaceutics
IS - 12
M1 - 1241
ER -