Benzyl- and dibenzyl tetrahydropyridinylidene ammonium salts with antiplasmodial and antitrypanosomal activity

Werner Seebacher*, Marcel Kaiser, Pascal Maeser, Robert Saf, Eva-Maria Pferschy-Wenzig, Robert Weis

*Korrespondierende/r Autor/-in für diese Arbeit

Publikation: Beitrag in einer FachzeitschriftArtikelBegutachtung

Abstract

Several 1-benzyl and 1,3-dibenzyl derivatives of tetrahydropyridinylidene salts with differing electron withdrawing substituents at the aromatic residues have been prepared. In addition, the amine moiety in position 4 was varied. The new compounds were investigated for their antiplasmodial and antitrypanosomal activities as well as for their cytotoxicity. They were characterized using FT-IR, HRMS and NMR spectroscopy. Structure–activity relationships including reported compounds are discussed. Graphical abstract: [Figure not available: see fulltext.].

Originalspracheenglisch
Seiten (von - bis)105-114
Seitenumfang10
FachzeitschriftMonatshefte fur Chemie
Jahrgang154
Ausgabenummer1
Frühes Online-Datum20 Nov. 2022
DOIs
PublikationsstatusVeröffentlicht - Jan. 2023

ASJC Scopus subject areas

  • Chemie (insg.)

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