TY - JOUR
T1 - Benzyl- and dibenzyl tetrahydropyridinylidene ammonium salts with antiplasmodial and antitrypanosomal activity
AU - Seebacher, Werner
AU - Kaiser, Marcel
AU - Maeser, Pascal
AU - Saf, Robert
AU - Pferschy-Wenzig, Eva-Maria
AU - Weis, Robert
PY - 2023/1
Y1 - 2023/1
N2 - Several 1-benzyl and 1,3-dibenzyl derivatives of tetrahydropyridinylidene salts with differing electron withdrawing substituents at the aromatic residues have been prepared. In addition, the amine moiety in position 4 was varied. The new compounds were investigated for their antiplasmodial and antitrypanosomal activities as well as for their cytotoxicity. They were characterized using FT-IR, HRMS and NMR spectroscopy. Structure–activity relationships including reported compounds are discussed. Graphical abstract: [Figure not available: see fulltext.].
AB - Several 1-benzyl and 1,3-dibenzyl derivatives of tetrahydropyridinylidene salts with differing electron withdrawing substituents at the aromatic residues have been prepared. In addition, the amine moiety in position 4 was varied. The new compounds were investigated for their antiplasmodial and antitrypanosomal activities as well as for their cytotoxicity. They were characterized using FT-IR, HRMS and NMR spectroscopy. Structure–activity relationships including reported compounds are discussed. Graphical abstract: [Figure not available: see fulltext.].
KW - Antiprotozoal activity
KW - Alkylations
KW - Structure-activity relationships
KW - Heterocycles
KW - Drug research
KW - Structure–activity relationships
UR - http://www.scopus.com/inward/record.url?scp=85142294238&partnerID=8YFLogxK
U2 - 10.1007/s00706-022-03003-w
DO - 10.1007/s00706-022-03003-w
M3 - Article
SN - 0026-9247
VL - 154
SP - 105
EP - 114
JO - Monatshefte fur Chemie
JF - Monatshefte fur Chemie
IS - 1
ER -