Abstract
Candida tenuis xylose reductase shows high catalytic efficiencies in carbonyl reduction of acetophenone and 1-phenyl-1-propanone derivatives. The quite low substrate solubility in aqueous buffer systems is circumvented by addition of methanol or by two-phase solvent systems. In the latter, methanol improves the substrate phase transfer as solvent mediator and leads to reasonable space/time yields. Resulting enantiomerically pure chiral alcohols are key intermediates for synthesis of active pharmaceutical ingredients. (R)-Atomoxetine is exemplarily synthesized in four steps, and the further use for generation of other oxetine derivatives and a polo-like kinase 1 inhibitor are discussed
Originalsprache | englisch |
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Seiten (von - bis) | 847-853 |
Fachzeitschrift | Chirality |
Jahrgang | 24 |
Ausgabenummer | 10 |
DOIs | |
Publikationsstatus | Veröffentlicht - 2012 |
Fields of Expertise
- Human- & Biotechnology