Candida tenuis Xylose Reductase Catalysed Reduction of Aryl Ketones for Enantioselective Synthesis of Active Pharmaceutical Ingredients

Michael Vogl, Regina Kratzer, Bernd Nidetzky, Lothar Brecker*

*Korrespondierende/r Autor/-in für diese Arbeit

Publikation: Beitrag in einer FachzeitschriftArtikelBegutachtung

Abstract

Candida tenuis xylose reductase shows high catalytic efficiencies in carbonyl reduction of acetophenone and 1-phenyl-1-propanone derivatives. The quite low substrate solubility in aqueous buffer systems is circumvented by addition of methanol or by two-phase solvent systems. In the latter, methanol improves the substrate phase transfer as solvent mediator and leads to reasonable space/time yields. Resulting enantiomerically pure chiral alcohols are key intermediates for synthesis of active pharmaceutical ingredients. (R)-Atomoxetine is exemplarily synthesized in four steps, and the further use for generation of other oxetine derivatives and a polo-like kinase 1 inhibitor are discussed
Originalspracheenglisch
Seiten (von - bis)847-853
FachzeitschriftChirality
Jahrgang24
Ausgabenummer10
DOIs
PublikationsstatusVeröffentlicht - 2012

Fields of Expertise

  • Human- & Biotechnology

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