TY - JOUR
T1 - Enzymatic decarboxylation—an emerging reaction for chemicals production from renewable resources
AU - Kourist, Robert
AU - Guterl, Jan-Karl
AU - Miyamoto, Kenji
AU - Sieber, Volker
PY - 2014
Y1 - 2014
N2 - Decarboxylases are very useful tools for the defunctionalization of organic molecules under very mild reaction conditions. They have been applied for the synthesis of alcohols, carboxylic acids, diamines, terminal olefins, and other important chemicals. Moreover, several decarboxylases catalyze the fixation of carbon dioxide, which makes them promising catalysts for the utilization of this resource. Interestingly, several decarboxylases show promiscuous activities such as enzymatic racemization and stereoselective hydration. Despite this very high synthetic potential, large-scale processes are still rare and are mostly limited to fermentative approaches or to small-volume products. This Minireview gives an overview of the several recent, very promising applications both for the synthesis of high-value fine chemicals and biogenic bulk products and summarizes chances and limitations of this emerging class of biocatalysts
AB - Decarboxylases are very useful tools for the defunctionalization of organic molecules under very mild reaction conditions. They have been applied for the synthesis of alcohols, carboxylic acids, diamines, terminal olefins, and other important chemicals. Moreover, several decarboxylases catalyze the fixation of carbon dioxide, which makes them promising catalysts for the utilization of this resource. Interestingly, several decarboxylases show promiscuous activities such as enzymatic racemization and stereoselective hydration. Despite this very high synthetic potential, large-scale processes are still rare and are mostly limited to fermentative approaches or to small-volume products. This Minireview gives an overview of the several recent, very promising applications both for the synthesis of high-value fine chemicals and biogenic bulk products and summarizes chances and limitations of this emerging class of biocatalysts
KW - biocatalysis biotechnology carbon dioxide enzyme catalysis green chemistry
U2 - 10.1002/cctc.201300881
DO - 10.1002/cctc.201300881
M3 - Article
SN - 1867-3880
VL - 6
SP - 689
EP - 701
JO - ChemCatChem
JF - ChemCatChem
IS - 3
ER -