TY - JOUR
T1 - (R)-Selective Nitroaldol Reaction Catalyzed by Metal-Dependent Bacterial Hydroxynitrile Lyases
AU - Bekerle-Bogner, Myria
AU - Gruber-Khadjawi, Mandana
AU - Wiltsche, Helmar
AU - Wiedner, Romana
AU - Schwab, Helmut
AU - Steiner, Kerstin
PY - 2016
Y1 - 2016
N2 - The nitroaldol (Henry) reaction is a valuable C−C bond-forming reaction resulting in β-nitro alcohols, which are important building blocks for the synthesis of bioactive compounds. Metal-dependent bacterial hydroxynitrile lyases with a cupin fold couple nitromethane or nitroethane and various aldehydes to yield (R)-β-nitro alcohols with up to 90 % conversion and up to ≥99 % enantiomeric excess.
AB - The nitroaldol (Henry) reaction is a valuable C−C bond-forming reaction resulting in β-nitro alcohols, which are important building blocks for the synthesis of bioactive compounds. Metal-dependent bacterial hydroxynitrile lyases with a cupin fold couple nitromethane or nitroethane and various aldehydes to yield (R)-β-nitro alcohols with up to 90 % conversion and up to ≥99 % enantiomeric excess.
U2 - 10.1002/cctc.201600150
DO - 10.1002/cctc.201600150
M3 - Article
SN - 1867-3880
VL - 8
SP - 2214
EP - 2216
JO - ChemCatChem
JF - ChemCatChem
IS - 13
ER -