Abstract
Thiamine diphosphate (ThDP) dependent carboligases catalyze the formation of carbon-carbon bonds. These enzymes are prominent biocatalysts for the production of valuable α-hydroxy carbonyl compounds, which serve as key building blocks in the synthesis of various pharmaceuticals and fine chemicals. Carboligases act in selective manner to afford regio- and stereochemically defined products from simple starting materials. This review explores the catalytic prowess of carboligases for synthetic purposes and is aimed at providing a selection tool of enzymes for particular sets of substrates or desired products. The comprehensive overview encompasses structural insights, relationships of the currently known sequence space and practical applications with a focus on recent literature, showcasing carboligases as potent tools for sustainable and efficient synthesis.
Originalsprache | englisch |
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Fachzeitschrift | ChemCatChem |
DOIs | |
Publikationsstatus | Angenommen/In Druck - 2024 |
ASJC Scopus subject areas
- Katalyse
- Physikalische und Theoretische Chemie
- Organische Chemie
- Anorganische Chemie