A new method for the preparation of piperidin-4-ones

Michael Hoffelner; Werner Seebacher; Usama Hassan; Andreas Leitner; Robert Weis; Robert Saf

doi:10.1016/j.tet.2021.132189

A new method for the preparation of piperidin-4-ones

Michael Hoffelner, Werner Seebacher^*, Usama Hassan, Andreas Leitner, Robert Weis, Robert Saf

^*Corresponding author for this work

Institute for Chemistry and Technology of Materials (6380)

Research output: Contribution to journal › Article › peer-review

Abstract

We describe a new reduction process for the efficient preparation of various, especially 2-substituted, piperidin-4-ones which are not accessible by other reaction pathways until now. Tetrahydropyridinylidene salts (THPS) with differing substitution pattern are the educts of this reaction. These compounds are available by mainly two different reaction sequences and they can be further modified by insertion of various substituents before the targeted piperidin-4-ones are obtained.

Original language	English
Article number	132189
Journal	Tetrahedron
Volume	90
DOIs	https://doi.org/10.1016/j.tet.2021.132189
Publication status	Published - 18 Jun 2021

Keywords

2-Substituted piperidin-4-ones
Drug research
Selective reduction
Synthons
Tetrahydropyridinylidene salts

ASJC Scopus subject areas

Biochemistry
Drug Discovery
Organic Chemistry

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10.1016/j.tet.2021.132189

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title = "A new method for the preparation of piperidin-4-ones",

abstract = "We describe a new reduction process for the efficient preparation of various, especially 2-substituted, piperidin-4-ones which are not accessible by other reaction pathways until now. Tetrahydropyridinylidene salts (THPS) with differing substitution pattern are the educts of this reaction. These compounds are available by mainly two different reaction sequences and they can be further modified by insertion of various substituents before the targeted piperidin-4-ones are obtained.",

keywords = "2-Substituted piperidin-4-ones, Drug research, Selective reduction, Synthons, Tetrahydropyridinylidene salts",

author = "Michael Hoffelner and Werner Seebacher and Usama Hassan and Andreas Leitner and Robert Weis and Robert Saf",

note = "Funding Information: The authors acknowledge the financial support by the University of Graz . Publisher Copyright: {\textcopyright} 2021 The Author(s)",

year = "2021",

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doi = "10.1016/j.tet.2021.132189",

language = "English",

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T1 - A new method for the preparation of piperidin-4-ones

AU - Hoffelner, Michael

AU - Seebacher, Werner

AU - Hassan, Usama

AU - Leitner, Andreas

AU - Weis, Robert

AU - Saf, Robert

PY - 2021/6/18

Y1 - 2021/6/18

N2 - We describe a new reduction process for the efficient preparation of various, especially 2-substituted, piperidin-4-ones which are not accessible by other reaction pathways until now. Tetrahydropyridinylidene salts (THPS) with differing substitution pattern are the educts of this reaction. These compounds are available by mainly two different reaction sequences and they can be further modified by insertion of various substituents before the targeted piperidin-4-ones are obtained.

AB - We describe a new reduction process for the efficient preparation of various, especially 2-substituted, piperidin-4-ones which are not accessible by other reaction pathways until now. Tetrahydropyridinylidene salts (THPS) with differing substitution pattern are the educts of this reaction. These compounds are available by mainly two different reaction sequences and they can be further modified by insertion of various substituents before the targeted piperidin-4-ones are obtained.

KW - 2-Substituted piperidin-4-ones

KW - Drug research

KW - Selective reduction

KW - Synthons

KW - Tetrahydropyridinylidene salts

UR - http://www.scopus.com/inward/record.url?scp=85105498762&partnerID=8YFLogxK

U2 - 10.1016/j.tet.2021.132189

DO - 10.1016/j.tet.2021.132189

M3 - Article

AN - SCOPUS:85105498762

SN - 0040-4020

VL - 90

JO - Tetrahedron

JF - Tetrahedron

M1 - 132189

ER -

A new method for the preparation of piperidin-4-ones

Abstract

Keywords

ASJC Scopus subject areas

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