Advanced therapies of skin injuries

Tina Maver; Uroš Maver; Karin Stana Kleinschek; Irena Mlinaric-Rascan; Dragica Maja Smrke

doi:10.1007/s00508-015-0859-7

Advanced therapies of skin injuries

Tina Maver, Uroš Maver^*, Karin Stana Kleinschek, Irena Mlinaric-Rascan, Dragica Maja Smrke

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

Abstract

The loss of tissue is still one of the most challenging problems in healthcare. Efficient laboratory expansion of skin tissue to reproduce the skins barrier function can make the difference between life and death for patients with extensive full-thickness burns, chronic wounds, or genetic disorders such as bullous conditions. This engineering has been initiated based on the acute need in the 1980s and today, tissue-engineered skin is the reality. The human skin equivalents are available not only as models for permeation and toxicity screening, but are frequently applied in vivo as clinical skin substitutes. This review aims to introduce the most important recent development in the extensive field of tissue engineering and to describe already approved, commercially available skin substitutes in clinical use.

Original language	English
Pages (from-to)	187-198
Number of pages	12
Journal	Wiener Klinische Wochenschrift
Volume	127
DOIs	https://doi.org/10.1007/s00508-015-0859-7
Publication status	Published - 1 Dec 2015
Externally published	Yes

Keywords

Allograft
Autograft
Scaffold
Tissue engineering
Tissue-engineered skin

ASJC Scopus subject areas

Medicine(all)

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1007/s00508-015-0859-7

Cite this

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title = "Advanced therapies of skin injuries",

abstract = "The loss of tissue is still one of the most challenging problems in healthcare. Efficient laboratory expansion of skin tissue to reproduce the skins barrier function can make the difference between life and death for patients with extensive full-thickness burns, chronic wounds, or genetic disorders such as bullous conditions. This engineering has been initiated based on the acute need in the 1980s and today, tissue-engineered skin is the reality. The human skin equivalents are available not only as models for permeation and toxicity screening, but are frequently applied in vivo as clinical skin substitutes. This review aims to introduce the most important recent development in the extensive field of tissue engineering and to describe already approved, commercially available skin substitutes in clinical use.",

keywords = "Allograft, Autograft, Scaffold, Tissue engineering, Tissue-engineered skin",

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T1 - Advanced therapies of skin injuries

AU - Maver, Tina

AU - Maver, Uroš

AU - Stana Kleinschek, Karin

AU - Mlinaric-Rascan, Irena

AU - Smrke, Dragica Maja

PY - 2015/12/1

Y1 - 2015/12/1

N2 - The loss of tissue is still one of the most challenging problems in healthcare. Efficient laboratory expansion of skin tissue to reproduce the skins barrier function can make the difference between life and death for patients with extensive full-thickness burns, chronic wounds, or genetic disorders such as bullous conditions. This engineering has been initiated based on the acute need in the 1980s and today, tissue-engineered skin is the reality. The human skin equivalents are available not only as models for permeation and toxicity screening, but are frequently applied in vivo as clinical skin substitutes. This review aims to introduce the most important recent development in the extensive field of tissue engineering and to describe already approved, commercially available skin substitutes in clinical use.

AB - The loss of tissue is still one of the most challenging problems in healthcare. Efficient laboratory expansion of skin tissue to reproduce the skins barrier function can make the difference between life and death for patients with extensive full-thickness burns, chronic wounds, or genetic disorders such as bullous conditions. This engineering has been initiated based on the acute need in the 1980s and today, tissue-engineered skin is the reality. The human skin equivalents are available not only as models for permeation and toxicity screening, but are frequently applied in vivo as clinical skin substitutes. This review aims to introduce the most important recent development in the extensive field of tissue engineering and to describe already approved, commercially available skin substitutes in clinical use.

KW - Allograft

KW - Autograft

KW - Scaffold

KW - Tissue engineering

KW - Tissue-engineered skin

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DO - 10.1007/s00508-015-0859-7

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AN - SCOPUS:84952874447

SN - 0043-5325

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JO - Wiener Klinische Wochenschrift

JF - Wiener Klinische Wochenschrift

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Advanced therapies of skin injuries

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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