Efwita Astria, Martin Simon Thonhofer, Raffaele Ricco, Weibin Liang, Chemelli Angela, Andrew Tarzia, Karen Alt, Christoph Hagemeyer, Johannes Rattenberger, Hartmuth Schröttner, Tanja Maria Wrodnigg, Heinz Amenitsch, David Huang, Christian Doonan, Paolo Falcaro

Research output: Contribution to journalArticlepeer-review


MOFs have demonstrated outstanding properties for the protectionand controlled release of different bio-entities, from proteins toliving cells. Carbohydrates, as pure molecules or as a component ofproteins and cells, perform essential biological functions. Thus, anunderstanding of the role of carbohydrates in the formationof MOF-based bio-composites will facilitate their application tobiotechnology and medicine. Here, we investigate the role ofcarbohydrate molecular weight and chemical functionalization inthe formation of carbohydrate@MOF composites. We find thatchemical functionalization, such as carboxylation, that leads to anenhancement of metal cation concentration at the surface of themolecule triggers the rapid self-assembly of the MOF material,zeolitic-imidazolate framework 8 (ZIF-8). Furthermore, we determinethe encapsulation efficiency and measure the release properties ofthe carbohydrate under controlled conditions. Our findings showthat MOFs can be used to prepare a new class of biocomposites forthe delivery of carbohydrate-based therapeutics.
Original languageEnglish
Pages (from-to)969-977
Number of pages9
JournalMaterials Horizons
Issue number5
Early online date20 Feb 2019
Publication statusPublished - 1 Jun 2019

ASJC Scopus subject areas

  • Materials Science(all)

Fields of Expertise

  • Advanced Materials Science

Treatment code (Nähere Zuordnung)

  • Basic - Fundamental (Grundlagenforschung)

Cite this