CFD Investigation of Non-Condensable Gases in Vacuum and Non-Vacuum Steam Sterilizers

Manuel Feurhuber, Marino Magno, Marco Miranda, René Josef Prieler, Christoph Hochenauer

Research output: Contribution to journalArticlepeer-review


Steam sterilization processes rely on high heat transfer rates from the steam to the medical devices. To guarantee this, all non-condensable gases (NCGs) must be removed from the steam sterilizer before sterilization. The ratios and distribution of the NCGs in the pre-sterilization phases of both a vacuum and a non-vacuum steam sterilizer are investigated. Two CFD models for simulation of the NCGs in the sterilizers were developed and validated by the measurements of a pressure sensor and eight thermocouples inside the steam sterilizer. Furthermore, a novel method was developed to calculate the real ratio of NCGs based on the standard measurement (EN 13060). The results show that the NCGs ratio defined in the EN 13060 did not accurately represent the real ratios of the NCGs.

Original languageEnglish
Pages (from-to)502-513
Number of pages12
JournalChemie - Ingenieur - Technik
Issue number4
Early online date21 Jan 2019
Publication statusPublished - Apr 2019


  • Autoclaves
  • Computational fluid dynamics
  • Heat transfer
  • Non-condensable gases
  • Steam sterilizers
  • Wall condensation

ASJC Scopus subject areas

  • General Chemical Engineering
  • General Chemistry
  • Industrial and Manufacturing Engineering


Dive into the research topics of 'CFD Investigation of Non-Condensable Gases in Vacuum and Non-Vacuum Steam Sterilizers'. Together they form a unique fingerprint.

Cite this