Chemoenzymatic synthesis of the cephalosporin intermediate 7-amino-3-alkenylcephem-4-carboxylic acid

Ferdinand Zepeck; Herbert Schleich; Klaus Totschnig; Peter Remler; Birgit Seisser; Gernot Strohmeier

Chemoenzymatic synthesis of the cephalosporin intermediate 7-amino-3-alkenylcephem-4-carboxylic acid

Ferdinand Zepeck (Inventor), Herbert Schleich (Inventor), Klaus Totschnig (Inventor), Peter Remler (Inventor), Birgit Seisser (Inventor), Gernot Strohmeier (Inventor)

Research output: Patent

Abstract

The invention relates to processes for the prepn. of 7-amino-3-alkenylcephem-4-carboxylic acid (I) and the compds. II and III by using the enzymes p-nitrobenzyl esterase and penicillin G amidase. The processes either start from the compd. I or the compd. of Formula III.

Original language	English
Patent number	WO2015071493
IPC	C12P35/00
Priority date	18/11/13
Publication status	Published - 21 May 2015

Keywords

p-nitrobenzyl esterase
penicillin G amidase
cephalosporine

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title = "Chemoenzymatic synthesis of the cephalosporin intermediate 7-amino-3-alkenylcephem-4-carboxylic acid",

abstract = "The invention relates to processes for the prepn. of 7-amino-3-alkenylcephem-4-carboxylic acid (I) and the compds. II and III by using the enzymes p-nitrobenzyl esterase and penicillin G amidase. The processes either start from the compd. I or the compd. of Formula III.",

keywords = "p-nitrobenzyl esterase, penicillin G amidase, cephalosporine",

author = "Ferdinand Zepeck and Herbert Schleich and Klaus Totschnig and Peter Remler and Birgit Seisser and Gernot Strohmeier",

year = "2015",

month = may,

day = "21",

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type = "Patent",

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T1 - Chemoenzymatic synthesis of the cephalosporin intermediate 7-amino-3-alkenylcephem-4-carboxylic acid

AU - Zepeck, Ferdinand

AU - Schleich, Herbert

AU - Totschnig, Klaus

AU - Remler, Peter

AU - Seisser, Birgit

AU - Strohmeier, Gernot

PY - 2015/5/21

Y1 - 2015/5/21

N2 - The invention relates to processes for the prepn. of 7-amino-3-alkenylcephem-4-carboxylic acid (I) and the compds. II and III by using the enzymes p-nitrobenzyl esterase and penicillin G amidase. The processes either start from the compd. I or the compd. of Formula III.

AB - The invention relates to processes for the prepn. of 7-amino-3-alkenylcephem-4-carboxylic acid (I) and the compds. II and III by using the enzymes p-nitrobenzyl esterase and penicillin G amidase. The processes either start from the compd. I or the compd. of Formula III.

KW - p-nitrobenzyl esterase

KW - penicillin G amidase

KW - cephalosporine

M3 - Patent

M1 - WO2015071493

ER -

Chemoenzymatic synthesis of the cephalosporin intermediate 7-amino-3-alkenylcephem-4-carboxylic acid

Abstract

Keywords

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