Detection of Pancreatic Ductal Adenocarcinoma by Ex Vivo Magnetic Levitation of Plasma Protein-Coated Nanoparticles

Luca Digiacomo; Erica Quagliarini; Vincenzo La Vaccara; Alessandro Coppola; Roberto Coppola; Damiano Caputo; Heinz Amenitsch; Barbara Sartori; Giulio Caracciolo; Daniela Pozzi

doi:10.3390/cancers13205155

Detection of Pancreatic Ductal Adenocarcinoma by Ex Vivo Magnetic Levitation of Plasma Protein-Coated Nanoparticles

Luca Digiacomo, Erica Quagliarini, Vincenzo La Vaccara, Alessandro Coppola, Roberto Coppola, Damiano Caputo, Heinz Amenitsch, Barbara Sartori, Giulio Caracciolo, Daniela Pozzi^*

^*Corresponding author for this work

Institute of Inorganic Chemistry (6330)

Research output: Contribution to journal › Article › peer-review

Abstract

Pancreatic Ductal Adeno Carcinoma (PDAC) is one of the most lethal malignancies worldwide, and the development of sensitive and specific technologies for its early diagnosis is vital to reduce morbidity and mortality rates. In this proof‐of‐concept study, we demonstrate the diagnostic ability of magnetic levitation (MagLev) to detect PDAC by using levitation of graphene oxide (GO) nanoparticles (NPs) decorated by a biomolecular corona of human plasma proteins collected from PDAC and non‐oncological patients (NOP). Levitation profiles of corona‐coated GO NPs injected in a MagLev device filled with a paramagnetic solution of dysprosium(III) nitrate hydrate in water enables to distinguish PDAC patients from NOP with 80% specificity, 100% sensitivity, and global classification accuracy of 90%. Our findings indicate that Maglev could be a robust and instrumental tool for the early detection of PDAC and other cancers.

Original language	English
Article number	5155
Number of pages	13
Journal	Cancers
Volume	13
Issue number	20
DOIs	https://doi.org/10.3390/cancers13205155
Publication status	Published - 2 Oct 2021

Keywords

pancreatic ductal adenocarcinoma
magnetic levitation
protein corona
graphene oxide
early cancer diagnosis
Early cancer diagnosis
Pancreatic ductal adenocarcinoma
Graphene oxide
Protein corona
Magnetic levitation

ASJC Scopus subject areas

Oncology
Cancer Research

Fields of Expertise

Advanced Materials Science

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.3390/cancers13205155Licence: CC BY 4.0

Cite this

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title = "Detection of Pancreatic Ductal Adenocarcinoma by Ex Vivo Magnetic Levitation of Plasma Protein-Coated Nanoparticles",

abstract = "Pancreatic Ductal Adeno Carcinoma (PDAC) is one of the most lethal malignancies worldwide, and the development of sensitive and specific technologies for its early diagnosis is vital to reduce morbidity and mortality rates. In this proof‐of‐concept study, we demonstrate the diagnostic ability of magnetic levitation (MagLev) to detect PDAC by using levitation of graphene oxide (GO) nanoparticles (NPs) decorated by a biomolecular corona of human plasma proteins collected from PDAC and non‐oncological patients (NOP). Levitation profiles of corona‐coated GO NPs injected in a MagLev device filled with a paramagnetic solution of dysprosium(III) nitrate hydrate in water enables to distinguish PDAC patients from NOP with 80% specificity, 100% sensitivity, and global classification accuracy of 90%. Our findings indicate that Maglev could be a robust and instrumental tool for the early detection of PDAC and other cancers.",

keywords = "pancreatic ductal adenocarcinoma, magnetic levitation, protein corona, graphene oxide, early cancer diagnosis, Early cancer diagnosis, Pancreatic ductal adenocarcinoma, Graphene oxide, Protein corona, Magnetic levitation",

author = "Luca Digiacomo and Erica Quagliarini and {La Vaccara}, Vincenzo and Alessandro Coppola and Roberto Coppola and Damiano Caputo and Heinz Amenitsch and Barbara Sartori and Giulio Caracciolo and Daniela Pozzi",

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doi = "10.3390/cancers13205155",

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T1 - Detection of Pancreatic Ductal Adenocarcinoma by Ex Vivo Magnetic Levitation of Plasma Protein-Coated Nanoparticles

AU - Digiacomo, Luca

AU - Quagliarini, Erica

AU - La Vaccara, Vincenzo

AU - Coppola, Alessandro

AU - Coppola, Roberto

AU - Caputo, Damiano

AU - Amenitsch, Heinz

AU - Sartori, Barbara

AU - Caracciolo, Giulio

AU - Pozzi, Daniela

PY - 2021/10/2

Y1 - 2021/10/2

N2 - Pancreatic Ductal Adeno Carcinoma (PDAC) is one of the most lethal malignancies worldwide, and the development of sensitive and specific technologies for its early diagnosis is vital to reduce morbidity and mortality rates. In this proof‐of‐concept study, we demonstrate the diagnostic ability of magnetic levitation (MagLev) to detect PDAC by using levitation of graphene oxide (GO) nanoparticles (NPs) decorated by a biomolecular corona of human plasma proteins collected from PDAC and non‐oncological patients (NOP). Levitation profiles of corona‐coated GO NPs injected in a MagLev device filled with a paramagnetic solution of dysprosium(III) nitrate hydrate in water enables to distinguish PDAC patients from NOP with 80% specificity, 100% sensitivity, and global classification accuracy of 90%. Our findings indicate that Maglev could be a robust and instrumental tool for the early detection of PDAC and other cancers.

AB - Pancreatic Ductal Adeno Carcinoma (PDAC) is one of the most lethal malignancies worldwide, and the development of sensitive and specific technologies for its early diagnosis is vital to reduce morbidity and mortality rates. In this proof‐of‐concept study, we demonstrate the diagnostic ability of magnetic levitation (MagLev) to detect PDAC by using levitation of graphene oxide (GO) nanoparticles (NPs) decorated by a biomolecular corona of human plasma proteins collected from PDAC and non‐oncological patients (NOP). Levitation profiles of corona‐coated GO NPs injected in a MagLev device filled with a paramagnetic solution of dysprosium(III) nitrate hydrate in water enables to distinguish PDAC patients from NOP with 80% specificity, 100% sensitivity, and global classification accuracy of 90%. Our findings indicate that Maglev could be a robust and instrumental tool for the early detection of PDAC and other cancers.

KW - pancreatic ductal adenocarcinoma

KW - magnetic levitation

KW - protein corona

KW - graphene oxide

KW - early cancer diagnosis

KW - Early cancer diagnosis

KW - Pancreatic ductal adenocarcinoma

KW - Graphene oxide

KW - Protein corona

KW - Magnetic levitation

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U2 - 10.3390/cancers13205155

DO - 10.3390/cancers13205155

M3 - Article

SN - 2072-6694

VL - 13

JO - Cancers

JF - Cancers

IS - 20

M1 - 5155

ER -

Detection of Pancreatic Ductal Adenocarcinoma by Ex Vivo Magnetic Levitation of Plasma Protein-Coated Nanoparticles

Abstract

Keywords

ASJC Scopus subject areas

Fields of Expertise

UN SDGs

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