TY - JOUR
T1 - Manipulating drug release from tridimensional porous substrates coated by initiated chemical vapor deposition
AU - Ghasemi-Mobarakeh, Laleh
AU - Werzer, Oliver
AU - Keimel, Roman
AU - Kolahreez, Davood
AU - Hadley, Peter
AU - Coclite, Anna Maria
PY - 2019
Y1 - 2019
N2 - In the recent years, modern wound dressings have attracted much interest to accelerate wound healing processes with the topical delivery of drugs directly on wounds having a significant effect on wound rehabilitation. The objective of this study was to develop a model dressing that would not only provide wound protection from the environment but might also provide the possibility to keep it moist and deliver a drug for potential speeding the healing process. Poly(ethylene terephthalate), cotton fabrics, and polycaprolactone (PCL) nanofibers were used as different tridimensional porous substrates, loaded with a model drug, clotrimazole. The results show that the chemical structure and surface area to volume ratio of the pristine substrates affect the drug release profile. Coating of such substrates by hydrogels poly(2-hydroxyethyl methacrylate) (p-HEMA) and poly(methacrylic acid) (p-MAA) was successfully achieved by initiated chemical vapor deposition. This method was chosen because it is gentle and solventless and most important it can coat free areas within the three-dimensional structures. Scanning electron microscopy results revealed that p-HEMA and p-MAA conformally coated the fibers of the substrates. Moreover, drug release experiments showed that p-HEMA and p-MAA coatings provide barriers preventing sudden drug release. In conclusion, our results indicated the possibility of fabricating dressings containing a drug with tunable drug release profile depending on several parameters even though a strong porous structure exists.
AB - In the recent years, modern wound dressings have attracted much interest to accelerate wound healing processes with the topical delivery of drugs directly on wounds having a significant effect on wound rehabilitation. The objective of this study was to develop a model dressing that would not only provide wound protection from the environment but might also provide the possibility to keep it moist and deliver a drug for potential speeding the healing process. Poly(ethylene terephthalate), cotton fabrics, and polycaprolactone (PCL) nanofibers were used as different tridimensional porous substrates, loaded with a model drug, clotrimazole. The results show that the chemical structure and surface area to volume ratio of the pristine substrates affect the drug release profile. Coating of such substrates by hydrogels poly(2-hydroxyethyl methacrylate) (p-HEMA) and poly(methacrylic acid) (p-MAA) was successfully achieved by initiated chemical vapor deposition. This method was chosen because it is gentle and solventless and most important it can coat free areas within the three-dimensional structures. Scanning electron microscopy results revealed that p-HEMA and p-MAA conformally coated the fibers of the substrates. Moreover, drug release experiments showed that p-HEMA and p-MAA coatings provide barriers preventing sudden drug release. In conclusion, our results indicated the possibility of fabricating dressings containing a drug with tunable drug release profile depending on several parameters even though a strong porous structure exists.
KW - clotrimazole
KW - drug release
KW - initiated chemical vapor deposition (iCVD)
KW - poly(2-hydroxyethyl methacrylate) (p-HEMA)
KW - poly(methacrylic acid) (p-MAA)
UR - http://www.scopus.com/inward/record.url?scp=85065037114&partnerID=8YFLogxK
UR - https://graz.pure.elsevier.com/en/publications/manipulating-drug-release-from-tridimensional-porous-substrates-coated-by-initiated-chemical-vapor-deposition(508b4c90-731d-4f7c-81e3-5000729c3d44).html
U2 - 10.1002/app.47858
DO - 10.1002/app.47858
M3 - Article
AN - SCOPUS:85065037114
VL - 136
JO - Journal of Applied Polymer Science
JF - Journal of Applied Polymer Science
SN - 0021-8995
IS - 33
M1 - 47858
ER -