Microprobe-based Terahertz Near-field Imaging of Highly Scattering Pharmaceutical Coatings on Small Tablets

Matthias Wolfgang; Alexander Michalski; Michael Nagel; Simon Sawallich; Martin Spoerk; Johannes G. Khinast

doi:10.1109/IRMMW-THz57677.2023.10299100

Microprobe-based Terahertz Near-field Imaging of Highly Scattering Pharmaceutical Coatings on Small Tablets

Matthias Wolfgang^*, Alexander Michalski, Michael Nagel, Simon Sawallich, Martin Spoerk, Johannes G. Khinast

^*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceeding › Conference paper › peer-review

Abstract

Pharmaceutical solid dosage forms can be inspected using terahertz time-domain spectroscopy systems. However, in many cases, the size, shape, and composition pose considerable challenges using classic far-field configurations. We demonstrate how these challenges can be overcome using microprobe-based THz near-field imaging in reflection-mode and a wavelet-based signal analysis algorithm. This technique reveals buried interface structures that were not resolvable before.

Original language	English
Title of host publication	IRMMW-THz 2023 - 48th Conference on Infrared, Millimeter, and Terahertz Waves
Publisher	IEEE Computer Society
ISBN (Electronic)	9798350336603
DOIs	https://doi.org/10.1109/IRMMW-THz57677.2023.10299100
Publication status	Published - 2023
Event	48th International Conference on Infrared, Millimeter, and Terahertz Waves: IRMMW-THz 2023 - Montreal, Canada Duration: 17 Sept 2023 → 22 Sept 2023

Conference

Conference	48th International Conference on Infrared, Millimeter, and Terahertz Waves
Abbreviated title	IRMMW-THz 2023
Country/Territory	Canada
City	Montreal
Period	17/09/23 → 22/09/23

ASJC Scopus subject areas

Energy Engineering and Power Technology
Electrical and Electronic Engineering

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10.1109/IRMMW-THz57677.2023.10299100

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Microprobe-based Terahertz Near-field Imaging of Highly Scattering Pharmaceutical Coatings on Small Tablets. / Wolfgang, Matthias; Michalski, Alexander; Nagel, Michael et al.
IRMMW-THz 2023 - 48th Conference on Infrared, Millimeter, and Terahertz Waves. IEEE Computer Society, 2023.

Research output: Chapter in Book/Report/Conference proceeding › Conference paper › peer-review

Wolfgang, M, Michalski, A, Nagel, M, Sawallich, S, Spoerk, M & Khinast, JG 2023, Microprobe-based Terahertz Near-field Imaging of Highly Scattering Pharmaceutical Coatings on Small Tablets. in IRMMW-THz 2023 - 48th Conference on Infrared, Millimeter, and Terahertz Waves. IEEE Computer Society, 48th International Conference on Infrared, Millimeter, and Terahertz Waves, Montreal, Canada, 17/09/23. https://doi.org/10.1109/IRMMW-THz57677.2023.10299100

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author = "Matthias Wolfgang and Alexander Michalski and Michael Nagel and Simon Sawallich and Martin Spoerk and Khinast, {Johannes G.}",

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AU - Nagel, Michael

AU - Sawallich, Simon

AU - Spoerk, Martin

AU - Khinast, Johannes G.

PY - 2023

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AB - Pharmaceutical solid dosage forms can be inspected using terahertz time-domain spectroscopy systems. However, in many cases, the size, shape, and composition pose considerable challenges using classic far-field configurations. We demonstrate how these challenges can be overcome using microprobe-based THz near-field imaging in reflection-mode and a wavelet-based signal analysis algorithm. This technique reveals buried interface structures that were not resolvable before.

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DO - 10.1109/IRMMW-THz57677.2023.10299100

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AN - SCOPUS:85177688580

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Microprobe-based Terahertz Near-field Imaging of Highly Scattering Pharmaceutical Coatings on Small Tablets

Abstract

Conference

ASJC Scopus subject areas

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