Rescuing DNA repair activity by rewiring the H-atom transfer pathway in the radical SAM enzyme, spore photoproduct lyase

Alhosna Benjdia*, Korbinian Heil, Andreas Winkler, Thomas Carell, Ilme Schlichting

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


The radical SAM enzyme, spore photoproduct lyase, requires an H-atom transfer (HAT) pathway to catalyze DNA repair. By rational engineering, we demonstrate that it is possible to rewire its HAT pathway, a first step toward the development of novel catalysts based on the radical SAM enzyme scaffold.
Original languageEnglish
Pages (from-to)14201-14204
JournalChemical Communications
Publication statusPublished - 2014
Externally publishedYes

Fields of Expertise

  • Human- & Biotechnology

Treatment code (Nähere Zuordnung)

  • Basic - Fundamental (Grundlagenforschung)

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