Synthesis and in vivo investigation of therapeutic effect of magnetite nanofluids in mouse prostate cancer model

J. Markhulia; Sh Kekutia; N. Mitskevich; V. Mikelashvili; L. Saneblidze; N. Leladze; Z. Jabua; L. Sacarescu; M. Kriechbaum; L. Almásy

Synthesis and in vivo investigation of therapeutic effect of magnetite nanofluids in mouse prostate cancer model

J. Markhulia^*, Sh Kekutia, N. Mitskevich, V. Mikelashvili, L. Saneblidze, N. Leladze, Z. Jabua, L. Sacarescu, M. Kriechbaum, L. Almásy

^*Corresponding author for this work

Institute of Inorganic Chemistry (6330)

Research output: Contribution to journal › Article › peer-review

Abstract

Nanofluids containing superparamagnetic iron oxide nanoparticles (SPIONs) stabilized with a biocompatible polymer polyethylene glycol (PEG) of molecular weight 4000 were synthesized by suitable modification of the standard synthetic procedure with a controlled co-precipitation technique in one-pot approach in a vacuum environment. The obtained samples were characterized using X-ray diffraction (XRD), Fourier Transform Infrared Spectroscopy (FTIR), Small-Angle X-ray Scattering (SAXS), Transmission Electron Microscopy (TEM) and Vibrating Sample Magnetometry (VSM). The therapeutic effect of magnetic nanofluids containing bare and PEG-coated magnetite nanoparticles has been studied in either monotherapy or combined therapy with anticancer drug mitoxantrone in mouse prostate cancer model. The therapeutic effect was the strongest in combined use of mitoxantrone with magnetite nanoparticles.

Original language	English
Pages (from-to)	1081-1090
Number of pages	10
Journal	Digest Journal of Nanomaterials and Biostructures
Volume	13
Issue number	4
Publication status	Published - 1 Oct 2018

Keywords

Iron oxide nanoparticles
Mitoxantrone
Nanomedicine
Österreich

ASJC Scopus subject areas

Structural Biology
Atomic and Molecular Physics, and Optics
Biomedical Engineering
Materials Science(all)
Condensed Matter Physics
Physical and Theoretical Chemistry

Fields of Expertise

Advanced Materials Science

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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https://chalcogen.ro/1081_MarkhuliaJ.pdfLicence: CC BY 4.0

Cite this

Markhulia, J., Kekutia, S., Mitskevich, N., Mikelashvili, V., Saneblidze, L., Leladze, N., Jabua, Z., Sacarescu, L., Kriechbaum, M., & Almásy, L. (2018). Synthesis and in vivo investigation of therapeutic effect of magnetite nanofluids in mouse prostate cancer model. Digest Journal of Nanomaterials and Biostructures, 13(4), 1081-1090. https://chalcogen.ro/1081_MarkhuliaJ.pdf

Markhulia, J, Kekutia, S, Mitskevich, N, Mikelashvili, V, Saneblidze, L, Leladze, N, Jabua, Z, Sacarescu, L, Kriechbaum, M & Almásy, L 2018, 'Synthesis and in vivo investigation of therapeutic effect of magnetite nanofluids in mouse prostate cancer model', Digest Journal of Nanomaterials and Biostructures, vol. 13, no. 4, pp. 1081-1090. <https://chalcogen.ro/1081_MarkhuliaJ.pdf>

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abstract = "Nanofluids containing superparamagnetic iron oxide nanoparticles (SPIONs) stabilized with a biocompatible polymer polyethylene glycol (PEG) of molecular weight 4000 were synthesized by suitable modification of the standard synthetic procedure with a controlled co-precipitation technique in one-pot approach in a vacuum environment. The obtained samples were characterized using X-ray diffraction (XRD), Fourier Transform Infrared Spectroscopy (FTIR), Small-Angle X-ray Scattering (SAXS), Transmission Electron Microscopy (TEM) and Vibrating Sample Magnetometry (VSM). The therapeutic effect of magnetic nanofluids containing bare and PEG-coated magnetite nanoparticles has been studied in either monotherapy or combined therapy with anticancer drug mitoxantrone in mouse prostate cancer model. The therapeutic effect was the strongest in combined use of mitoxantrone with magnetite nanoparticles.",

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AU - Markhulia, J.

AU - Kekutia, Sh

AU - Mitskevich, N.

AU - Mikelashvili, V.

AU - Saneblidze, L.

AU - Leladze, N.

AU - Jabua, Z.

AU - Sacarescu, L.

AU - Kriechbaum, M.

AU - Almásy, L.

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AB - Nanofluids containing superparamagnetic iron oxide nanoparticles (SPIONs) stabilized with a biocompatible polymer polyethylene glycol (PEG) of molecular weight 4000 were synthesized by suitable modification of the standard synthetic procedure with a controlled co-precipitation technique in one-pot approach in a vacuum environment. The obtained samples were characterized using X-ray diffraction (XRD), Fourier Transform Infrared Spectroscopy (FTIR), Small-Angle X-ray Scattering (SAXS), Transmission Electron Microscopy (TEM) and Vibrating Sample Magnetometry (VSM). The therapeutic effect of magnetic nanofluids containing bare and PEG-coated magnetite nanoparticles has been studied in either monotherapy or combined therapy with anticancer drug mitoxantrone in mouse prostate cancer model. The therapeutic effect was the strongest in combined use of mitoxantrone with magnetite nanoparticles.

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ER -

Synthesis and in vivo investigation of therapeutic effect of magnetite nanofluids in mouse prostate cancer model

Abstract

Keywords

ASJC Scopus subject areas

Fields of Expertise

UN SDGs

Access to Document

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