The Kv10.1 voltage-gated ion channel modeling based on control system theory

Jasmina Lozanovic Sajic*, Sonja Langthaler, Christian Baumgartner

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


In this paper, we present a control system theory based modeling approach for the voltage-gated ion-channel Kv10.1 at different temperatures. Kv10.1 is expressed in the central nervous system and the brain of healthy humans. The study of the activity of this ion channel is important, because its activity is associated with the occurrence of cancer in different organs or tissues. According to systems and control theory, the voltage-gated channel Kv10.1 was assumed to be a linear time-invariant system and, as such, exhibits dynamic behavior. The experimental results show that Kv10.1 operates as a first-order model based on the input voltage step protocol and the measured macroscopic ion current output.
Original languageEnglish
Article number1
Pages (from-to)01-04
Number of pages4
JournalCurrent Directions in Biomedical Engineering
Issue number2
Publication statusPublished - 1 Aug 2022

Fields of Expertise

  • Human- & Biotechnology

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