Improving the accuracy of Multipool-Lorentzian fitting in CEST MRI by use of a Pseudo-Voigt lineshape for direct water saturation

Activity: Talk or presentationPoster presentationScience to science


In Chemical Exchange Saturation Transfer (CEST) MRI one common analysis technique is Multipool-Lorentzian fitting of the resulting Z-Spectrum. Multiple Lorentzian lineshapes are fitted to the measured data. The lineshape of the direct water saturation (DS) can deviate substantially from a Lorentzian depending on the saturation scheme and B1. To prevent a cross-influence of the DS on the CEST and increase the fit accuracy we propose the use of a Pseudo-Voigt lineshape for the water line.
Period6 Jun 2023
Event titleISMRM & ISMRT Annual Meeting & Exhibition 2023
Event typeConference
LocationToronto, CanadaShow on map
Degree of RecognitionInternational