Controlling concentration of bioactive components in cat's claw based products with a hybrid separation process

Alba Calvo, Dániel Dévényi, Bence Kószó, Sergio Sanz, Anna Lisa Oelbermann, Markus Maier, Tibor Keve, Kinga Komka, Thomas Gamse, Eckhard Weidner, Edit Székely*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


Supercritical fluid extraction (SFE) with and without entrainer combined with organic solvent extraction was used for fractionation of bioactive natural products as alkaloids and antioxidants from cat's claw (Uncaria tomentosa (Willd.) DC.) bark. Extracts obtained from this plant have a number of beneficial effects, including anti-inflammatory or immune stimulator. The aim of this work was to obtain extracts of enriched and limited alkaloid concentrations, good antioxidants and tannin agents. The results demonstrated that a hybrid process involving SFE is a selective method to obtain an oxindole alkaloid rich fraction (186.0 ± 3.2 mg total pentacyclic oxindole alkaloids/g extract) and a product enriched in tannins (23.8 ± 1.9% tannin content in extract) and antioxidants (IC50 = 5.88 ± 0.54 μg/ml extract).

Original languageEnglish
Pages (from-to)50-55
Number of pages6
JournalThe Journal of Supercritical Fluids
Publication statusPublished - 1 Jul 2017


  • Antioxidants
  • Cat's claw
  • Co-solvent
  • Natural alkaloid
  • Supercritical fluid extraction
  • Tannins

ASJC Scopus subject areas

  • Chemical Engineering(all)
  • Condensed Matter Physics
  • Physical and Theoretical Chemistry

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