Derivatives of natural organocatalytic cofactors and artificial organocatalytic cofactors as catalysts in enzymes

Horst Lechner; Gustav Oberdorfer

doi:10.1002/cbic.202100599

Derivatives of natural organocatalytic cofactors and artificial organocatalytic cofactors as catalysts in enzymes

Horst Lechner, Gustav Oberdorfer

Institute of Biochemistry (6480)

Research output: Contribution to journal › Review article › peer-review

Abstract

Catalytically active non-metal cofactors in enzymes carry out a variety of different reactions. The efforts to develop derivatives of naturally occurring cofactors such as flavins or pyridoxal phosphate and the advances to design new, non-natural cofactors are reviewed here. We report the status quo for enzymes harboring organocatalysts as derivatives of natural cofactors or as artificial ones and their application in the asymmetric synthesis of various compounds.

Original language	English
Article number	e202100599
Number of pages	12
Journal	ChemBioChem
Volume	23
Issue number	13
Early online date	12 Apr 2022
DOIs	https://doi.org/10.1002/cbic.202100599
Publication status	Published - 5 Jul 2022

Keywords

biocatalysis
cofactors
enzyme engineering
organocatalysis

ASJC Scopus subject areas

Molecular Medicine
Molecular Biology
Biochemistry
Organic Chemistry

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cbic_21_00599Final published version, 4.86 MBLicence: CC BY 4.0

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AB - Catalytically active non-metal cofactors in enzymes carry out a variety of different reactions. The efforts to develop derivatives of naturally occurring cofactors such as flavins or pyridoxal phosphate and the advances to design new, non-natural cofactors are reviewed here. We report the status quo for enzymes harboring organocatalysts as derivatives of natural cofactors or as artificial ones and their application in the asymmetric synthesis of various compounds.

KW - biocatalysis

KW - cofactors

KW - enzyme engineering

KW - organocatalysis

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Derivatives of natural organocatalytic cofactors and artificial organocatalytic cofactors as catalysts in enzymes

Abstract

Keywords

ASJC Scopus subject areas

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