Efficient Encapsulation of Fluorinated Drugs in the Confined Space of Water-Dispersible Fluorous Supraparticles

Claudia Pigliacelli; Daniele Maiolo; Nonappa  Nonappa; Johannes S. Haataja; Heinz Amenitsch; Claire Michelet; Paola Sánchez Moreno; Ilaria Tirotta; Pierangelo Metrangolo; Francesca Baldelli Bombelli

doi:10.1002/anie.201710230

Efficient Encapsulation of Fluorinated Drugs in the Confined Space of Water-Dispersible Fluorous Supraparticles

Claudia Pigliacelli, Daniele Maiolo, Nonappa Nonappa, Johannes S. Haataja, Heinz Amenitsch, Claire Michelet, Paola Sánchez Moreno, Ilaria Tirotta, Pierangelo Metrangolo^*, Francesca Baldelli Bombelli

^*Corresponding author for this work

Institute of Inorganic Chemistry (6330)

Research output: Contribution to journal › Article › peer-review

Abstract

Fluorophobic-driven assemblies of gold nanomaterials were stabilized into water-dispersible fluorous supraparticles by the film-forming protein hydrophobin II. The strategy makes use of fluorous nanomaterials of different dimensions to engineer size and inner functionalization of the resulting confined space. The inner fluorous compartments allow efficient encapsulation and transport of high loadings of partially fluorinated drug molecules in water.

Original language	English
Pages (from-to)	16186-16190
Number of pages	5
Journal	Angewandte Chemie - International Edition
Volume	56
Issue number	51
DOIs	https://doi.org/10.1002/anie.201710230
Publication status	Published - 18 Dec 2017

Keywords

fluorous surfaces
gold nanoparticles
hydrophobin
self-assembly
supraparticles

ASJC Scopus subject areas

Catalysis
Chemistry(all)

Fields of Expertise

Advanced Materials Science
Human- & Biotechnology

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10.1002/anie.201710230

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Pigliacelli, C., Maiolo, D., Nonappa, N., Haataja, J. S., Amenitsch, H., Michelet, C., Sánchez Moreno, P., Tirotta, I., Metrangolo, P., & Baldelli Bombelli, F. (2017). Efficient Encapsulation of Fluorinated Drugs in the Confined Space of Water-Dispersible Fluorous Supraparticles. Angewandte Chemie - International Edition , 56(51), 16186-16190. https://doi.org/10.1002/anie.201710230

Pigliacelli, C, Maiolo, D, Nonappa, N, Haataja, JS, Amenitsch, H, Michelet, C, Sánchez Moreno, P, Tirotta, I, Metrangolo, P & Baldelli Bombelli, F 2017, 'Efficient Encapsulation of Fluorinated Drugs in the Confined Space of Water-Dispersible Fluorous Supraparticles', Angewandte Chemie - International Edition , vol. 56, no. 51, pp. 16186-16190. https://doi.org/10.1002/anie.201710230

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abstract = "Fluorophobic-driven assemblies of gold nanomaterials were stabilized into water-dispersible fluorous supraparticles by the film-forming protein hydrophobin II. The strategy makes use of fluorous nanomaterials of different dimensions to engineer size and inner functionalization of the resulting confined space. The inner fluorous compartments allow efficient encapsulation and transport of high loadings of partially fluorinated drug molecules in water.",

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AU - Pigliacelli, Claudia

AU - Maiolo, Daniele

AU - Nonappa, Nonappa

AU - Haataja, Johannes S.

AU - Amenitsch, Heinz

AU - Michelet, Claire

AU - Sánchez Moreno, Paola

AU - Tirotta, Ilaria

AU - Metrangolo, Pierangelo

AU - Baldelli Bombelli, Francesca

PY - 2017/12/18

Y1 - 2017/12/18

N2 - Fluorophobic-driven assemblies of gold nanomaterials were stabilized into water-dispersible fluorous supraparticles by the film-forming protein hydrophobin II. The strategy makes use of fluorous nanomaterials of different dimensions to engineer size and inner functionalization of the resulting confined space. The inner fluorous compartments allow efficient encapsulation and transport of high loadings of partially fluorinated drug molecules in water.

AB - Fluorophobic-driven assemblies of gold nanomaterials were stabilized into water-dispersible fluorous supraparticles by the film-forming protein hydrophobin II. The strategy makes use of fluorous nanomaterials of different dimensions to engineer size and inner functionalization of the resulting confined space. The inner fluorous compartments allow efficient encapsulation and transport of high loadings of partially fluorinated drug molecules in water.

KW - fluorous surfaces

KW - gold nanoparticles

KW - hydrophobin

KW - self-assembly

KW - supraparticles

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U2 - 10.1002/anie.201710230

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JO - Angewandte Chemie - International Edition

JF - Angewandte Chemie - International Edition

IS - 51

ER -

Efficient Encapsulation of Fluorinated Drugs in the Confined Space of Water-Dispersible Fluorous Supraparticles

Abstract

Keywords

ASJC Scopus subject areas

Fields of Expertise

Access to Document

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