Abstract
Within this study, we investigated a one-pot enzymatic redox cascade composed of different enoate reductases (5 EREDs from diverse bacterial origins) and various Baeyer-Villiger monooxygenases (4 BVMOs) with complementary regioselectivity that enabled access to six out of eight carvo-lactone stereoisomers starting from readily available natural carvones. Applicability of this two-step cascade was demonstrated by preparative scale experiments yielding up to 76% of the desired chiral carvolactone.
Original language | English |
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Pages (from-to) | 7389-7394 |
Number of pages | 6 |
Journal | Tetrahedron |
Volume | 74 |
Issue number | 52 |
DOIs | |
Publication status | Published - 27 Dec 2018 |
Keywords
- Baeyer-Villiger monooxygenases
- Biotransformation
- Carvone
- Cascade reaction
- Eonate reductase
- Redox enzymes
ASJC Scopus subject areas
- Biochemistry
- Drug Discovery
- Organic Chemistry