Chemoenzymatic one-pot reaction from carboxylic acid to nitrile via oxime

Melissa Horvat; Victoria Weilch; Robert Rädisch; Sebastian Hecko; Astrid Schiefer; Florian Rudroff; Birgit Wilding; Norbert Klempier; Miroslav Patek; Ludmila Martínková; Margit Winkler

doi:10.1039/D1CY01694F

Chemoenzymatic one-pot reaction from carboxylic acid to nitrile via oxime

Melissa Horvat, Victoria Weilch, Robert Rädisch, Sebastian Hecko, Astrid Schiefer, Florian Rudroff, Birgit Wilding, Norbert Klempier, Miroslav Patek, Ludmila Martínková, Margit Winkler^*

^*Korrespondierende/r Autor/-in für diese Arbeit

Publikation: Beitrag in einer Fachzeitschrift › Artikel › Begutachtung

Abstract

We report a new chemoenzymatic cascade starting with aldehyde synthesis by carboxylic acid reductase (CAR) followed by chemical in situ oxime formation. The final step to the nitrile is catalyzed by aldoxime dehydratase (Oxd). Full conversions of phenylacetic acid and hexanoic acid were achieved in a two-phase mode.

Originalsprache	englisch
Seiten (von - bis)	62-66
Seitenumfang	5
Fachzeitschrift	Catalysis Science & Technology
Jahrgang	12
Ausgabenummer	1
DOIs	https://doi.org/10.1039/D1CY01694F
Publikationsstatus	Veröffentlicht - 7 Jan. 2022

ASJC Scopus subject areas

Katalyse

Fields of Expertise

Human- & Biotechnology

Zugriff auf Dokument

10.1039/D1CY01694FLizenz: CC BY 4.0

Andere Dateien und Links

Verknüpfung zur Publikation in Scopus

1 Abgeschlossen

FWF - Nitriles - Neue chemoenzymatische Route von Säuren zu Nitrilen
Winkler, M. (Teilnehmer (Co-Investigator))
1/03/20 → 1/08/24
Projekt: Forschungsprojekt

3 Poster
3 Artikel
1 Review eines Fachbereichs (Review article)

Entwicklung einer zyanidfreien Kaskadenreaktion: Von nachhaltigen Rohstoffen zu wertvollen Nitrilen
Winkler, M. & Martínková, L., 20 Nov. 2024, in: Wiley Analytical Science Magazine. 2024
Publikation: Beitrag in einer Fachzeitschrift › Artikel › Begutachtung
Recent Advances on CARs
Winkler, M., Goj, D., Breuer, H., Horvat, M. & Martinková, L., 10 Juli 2024.
Publikation: Konferenzbeitrag › Poster
Bio-based valorization of lignin-derived phenolic compounds: a review
Martínková, L., Grulich, M., Pátek, M., Křístková, B. & Winkler, M., Mai 2023, in: Biomolecules. 13, 5, 25 S., 717.
Publikation: Beitrag in einer Fachzeitschrift › Review eines Fachbereichs (Review article) › Begutachtung

Open Access

Dieses zitieren

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abstract = "We report a new chemoenzymatic cascade starting with aldehyde synthesis by carboxylic acid reductase (CAR) followed by chemical in situ oxime formation. The final step to the nitrile is catalyzed by aldoxime dehydratase (Oxd). Full conversions of phenylacetic acid and hexanoic acid were achieved in a two-phase mode.",

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AU - Horvat, Melissa

AU - Weilch, Victoria

AU - Rädisch, Robert

AU - Hecko, Sebastian

AU - Schiefer, Astrid

AU - Rudroff, Florian

AU - Wilding, Birgit

AU - Klempier, Norbert

AU - Patek, Miroslav

AU - Martínková, Ludmila

AU - Winkler, Margit

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AB - We report a new chemoenzymatic cascade starting with aldehyde synthesis by carboxylic acid reductase (CAR) followed by chemical in situ oxime formation. The final step to the nitrile is catalyzed by aldoxime dehydratase (Oxd). Full conversions of phenylacetic acid and hexanoic acid were achieved in a two-phase mode.

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Chemoenzymatic one-pot reaction from carboxylic acid to nitrile via oxime

Abstract

ASJC Scopus subject areas

Fields of Expertise

Zugriff auf Dokument

Andere Dateien und Links

Fingerprint

Projekte

FWF - Nitriles - Neue chemoenzymatische Route von Säuren zu Nitrilen

Publikationen

Entwicklung einer zyanidfreien Kaskadenreaktion: Von nachhaltigen Rohstoffen zu wertvollen Nitrilen

Recent Advances on CARs

Bio-based valorization of lignin-derived phenolic compounds: a review

Dieses zitieren